Polypeptides that bind to DC-SIGN and/or its homologues and methods for using such peptides for the treatment of various disorders are described. DC-SIGN and its homologues are receptors that bind IgG antibodies or Fc fragments and mediate intravenous immunoglobulin (IVIG)-related reversal of inflammation associated with various immune disorders.
申请公布号
EP2793918(A1)
申请公布日期
2014.10.29
申请号
EP20120859843
申请日期
2012.12.10
申请人
THE ROCKEFELLER UNIVERSITY;SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH
发明人
RAVETCH, JEFFREY, V.;PINCETIC, ANDREW;WANG, PING;DANISHEFSKY, SAM