发明名称 |
COMPOUNDS FOR INHIBITING THE INTERACTION OF BCL2 WITH BINDING PARTNERS |
摘要 |
<p>The present invention relates to compounds of formula I: in which R1, R2, R3 and R4 are as defined in the Summary of the Invention. Compounds of formula I are capable of disrupting the BCL-2 interations with proteins containing a BH3 domain. Disrupting this interaction can restore the anti-apoptotic function of BCL-2 in cancer cells and tumor tissue expressing BCL-2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancerous diseases.</p> |
申请公布号 |
EP2794590(A1) |
申请公布日期 |
2014.10.29 |
申请号 |
EP20120805895 |
申请日期 |
2012.12.12 |
申请人 |
NOVARTIS AG |
发明人 |
VISSER, MICHAEL SCOTT;YUSUFF, NAEEM |
分类号 |
C07D401/10;A61K31/4725;A61P35/00;C07D409/14 |
主分类号 |
C07D401/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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