6-and 7-amino isoquinoline compounds and methods for making and using the same

摘要

6- and 7-amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6- and 7-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.

主权项

1. A compound according to Formula (I): any optical isomer, diastereomer, or enantiomer of Formula I or a physiologically acceptable salt or solvate thereof, wherein R1 is an aryl group, a heteroaryl group, a cycloalkyl group, a heterocycloalkyl group, R7 is hydrogen, C1-C4 alkyl, cyano, or R1 and R7 combine to form a ring of at least three and at most eight member atoms, R2, and R3 are, independently, hydrogen, hydroxyl, halogen, C1-C4 alkyl, C2-C4 alkenyl, C2-C4 alkynyl, amino, nitro, cyano, C1-C4 carbonyl, C1-C4 carbonylamino, C1-C4 alkoxy, C1-C4 sulfonyl, C1-C4 sulfonylamino, C1-C4 thioalkyl, C1-C4 carboxyl, cycloalkyl, heterocycloalkyl, aryl, C1-C4 alkyl aryl, heteroaryl, or C1-C4 alkyl heteroaryl; or R2 and R3 combine to form a ring of at least five and at most eight member atoms, X is a carbonyl group, a sulfone group, thiocarbonyl or methylene, and R4 and R5 are independently, halogen, hydrogen, hydroxy, alkyl, alkoxy, amino, carbonyl, cycloalkyl, heterocycloalkyl, aryl, C1-C4 alkyl aryl, heteroaryl, C1-C4 alkyl heteroaryl, alkenyl, alkynyl, nitro, cyano, C1-C4 carbonylamino, C1-C4 sulfonyl, C1-C4 sulfonylamino, C1-C4 thioalkyl or C1-C4 carboxyl.