| 发明名称 | Method for screening a glutamate release inhibitor in an astrocyte | ||
| 摘要 | The present invention investigate the two modes of glutamate release and the releasing rate of glutamate, and thus can provide a useful technique for neuron protection and acceleration of neurotransmission by controlling the glutamate release in astroctye. Thus, the present invention provides an inhibitor of the fast-mode release and/or the slow-mode release of astrocytic glutamate, a screening method of the inhibitor and a pharmaceutical composition or method of ameliorating, preventing and/or treating the disease associated with the over-release of glutamate via the Ca2+-activated anion channel, with the inhibition of fast-mode glutamate release. | ||
| 申请公布号 | US8871463(B2) | 申请公布日期 | 2014.10.28 |
| 申请号 | US201313948476 | 申请日期 | 2013.07.23 |
| 申请人 | Korea Institute of Science and Technology | 发明人 | Lee Changjoon Justin;Oh Soo Jin;Hwang Eun Mi;Woo Dong Ho |
| 分类号 | C12Q1/02 | 主分类号 | C12Q1/02 |
| 代理机构 | Staas & Halsey LLP | 代理人 | Staas & Halsey LLP |
| 主权项 | 1. A method for screening a glutamate-release inhibitor in an astrocyte, said method comprising the steps of: preparing an astrocyte-containing sample; contacting a candidate material to the sample; and detecting the activation of a glutamate-permeable potassium channel or Ca2+-activated anion channel in the sample, wherein said candidate material is determined to be glutamate-release inhibitor in an astrocyte when the channel is found to be inactivated. | ||
| 地址 | Seoul KR | ||