| 发明名称 | Anti-human folate receptor beta antibodies and methods of use | ||
| 摘要 | Human anti-human folate receptor beta (FRβ) antibodies and antigen-binding fragments thereof are described, as well as methods of using such antibodies and fragments to treat inflammatory disorders or cancers expressing cell surface FRβ. | ||
| 申请公布号 | US8871206(B2) | 申请公布日期 | 2014.10.28 |
| 申请号 | US201313790881 | 申请日期 | 2013.03.08 |
| 申请人 | Purdue Research Foundation;The United States of America, as Represented by the Secretary Department of Health and Human Services | 发明人 | Low Philip S.;Dimitrov Dimiter S.;Feng Yang;Shen Jiayin |
| 分类号 | C07K16/28;A61K47/48;A61K49/16;A61K9/127;A61K49/00;A61K38/00;A61K51/10;C07K14/705;A61K9/00 | 主分类号 | C07K16/28 |
| 代理机构 | Fish & Richardson P.C. | 代理人 | Fish & Richardson P.C. |
| 主权项 | 1. An isolated human monoclonal antibody, or an antigen-binding fragment thereof, that specifically binds human folate receptor β (FRβ), the antibody or fragment comprising: a heavy chain variable region (VH) CDR 1 comprising the amino acid sequence set forth in SEQ ID NO:1; a VH CDR2 comprising the amino acid sequence set forth in SEQ ID NO:2; a VH CDR3 comprising the amino acid sequence set forth in SEQ ID NO:3; a light chain variable region (VL) CDR1 comprising the amino acid sequence set forth in SEQ ID NO:14; a VL CDR2 comprising the amino acid sequence set forth in SEQ ID NO:15; and a VL CDR3 comprising the amino acid sequence set forth in SEQ ID NO:16. | ||
| 地址 | West Lafayette IN US | ||