Low total salt reagent compositions and systems for biosensors

摘要

A biosensor system for determining the concentration of an analyte in a sample is disclosed that includes a reaction means for selectively performing a redox reaction of an analyte, and a measurement means for measuring a rate of the redox reaction of the analyte. The reaction means includes a binder, a buffer salt, a mediator including at most 20% (w/w) of an inorganic, non-transition metal salt, and an enzyme system. The measurement means includes at least two conductors. The measurement means measures an output signal value from the reaction means at a maximum kinetic performance within at most 7 seconds of introducing a sample to the reaction means, where the output signal value is responsive to the concentration of the analyte in the sample, and the measurement means determines at least one ΔS value responsive to at least one error parameter. The measurement means further determines the analyte concentration in the sample from a compensation equation including at least one reference correlation and the at least one ΔS value, where the compensation equation has a R2 value of at least 0.5.

主权项

1. A biosensor system, for determining the concentration of an analyte in a sample, comprising:
a reaction means for selectively performing a redox reaction of an analyte,
where the reaction means comprises a binder, a buffer salt, a mediator comprising at most 20% (w/w) of an inorganic, non-transition metal salt, an enzyme system, and a non-ionic, sugar-based surfactant; and a measurement means for measuring a rate of the redox reaction of the analyte,
where the measurement means comprises at least two conductors; where the measurement means measures an output signal value from the reaction means at a maximum kinetic performance within at most 7 seconds of introducing a sample to the reaction means, where the output signal value is responsive to the concentration of the analyte in the sample, the measurement means is capable of determining at least one slope deviation of the correlation between analyte concentrations and output current values determined from one or more error parameters responsive to at least one error parameter, and the measurement means is capable of determining the analyte concentration in the sample from a compensation equation including at least one reference correlation and the at least one slope deviation of the correlation between analyte concentrations and output current values determined from one or more error parameters; where the compensation equation has a R2 value of at least 0.5.