| 发明名称 | Metaxalone cocrystals | ||
| 摘要 | The invention relates to improvements of the physiochemical and/or the pharmaceutical properties of metaxalone. Disclosed herein are several new cocrystals of metaxalone, including: a 1:1 metaxalone adipic acid cocrystal, a 1:0.5 metaxalone fumaric acid cocrystal, a 1:1 metaxalone salicyclic acid cocrystal, a 1:0.5 metaxalone succinic acid cocrystal, and a 1:0.5 metaxalone maleic acid cocrystal. The therapeutic uses of these metaxalone cocrystals are described as well as therapeutic compositions containing them. | ||
| 申请公布号 | US8871793(B2) | 申请公布日期 | 2014.10.28 |
| 申请号 | US201013518177 | 申请日期 | 2010.12.22 |
| 申请人 | Nuformix Limited | 发明人 | Holland Joanne;Frampton Christopher;Chorlton Alan;Gooding Daniel |
| 分类号 | A61K31/421;C07D263/24;C07C55/10;C07C65/10;C07C57/145;C07C57/15;C07C55/14 | 主分类号 | A61K31/421 |
| 代理机构 | J.A. Lindeman & Co., PLLC | 代理人 | J.A. Lindeman & Co., PLLC |
| 主权项 | 1. A metaxalone cocrystal selected from a 1:1 metaxalone adipic acid cocrystal, a 1:0.5 metaxalone fumaric acid cocrystal, a 1:1 metaxalone salicylic acid cocrystal, a 1:0.5 metaxalone succinic acid cocrystal, and a 1:0.5 metaxalone maleic acid cocrystal. | ||
| 地址 | GB | ||