| 发明名称 |
Polynucleotides encoding antibodies that bind both IL-17A and IL-17F |
| 摘要 |
The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A and IL-17F. IL-17A and IL-17F are cytokines that are involved in inflammatory processes and human disease. The present invention includes antibodies that bind both IL-17A and IL-17F, hybridomas that produce the antibodies, and methods of using the same in inflammation. |
| 申请公布号 |
US8871467(B2) |
申请公布日期 |
2014.10.28 |
| 申请号 |
US201313910311 |
申请日期 |
2013.06.05 |
| 申请人 |
ZymoGenetics, Inc. |
发明人 |
Jaspers Stephen R.;Presnell Scott R.;Huber Monica J. |
| 分类号 |
C12N15/09;C12N15/13;C12P21/08;C07K16/46;C07K16/24;G01N33/68;A61K39/00 |
主分类号 |
C12N15/09 |
| 代理机构 |
|
代理人 |
Walsh Brian J. |
| 主权项 |
1. An isolated polynucleotide encoding a cross-reactive monoclonal antibody which specifically binds to both IL-17A (SEQ ID NO:2) and IL-17F (SEQ ID NO:4), wherein the monoclonal antibody inhibits the binding of both IL-17A and IL-17F to IL-17RC, and wherein the monoclonal antibody is a humanized monoclonal antibody derived from the antibody produced by the hybridoma deposited with the American Type Culture Collection having the ATCC Patent Deposit Designation PTA-7988. |
| 地址 |
Seattle WA US |
