Biomarkers and methods for determining disease progression in nonalcoholic steatohepatitis (NASH)

摘要

Diets high in saturated fat and fructose have been implicated in the development of obesity and nonalcoholic steatohepatitis (NASH) in humans. Provided herein are biomarkers, methods, and animal models useful for the investigation and non-invasive detection of NASH, including a non-invasive biomarker that could be used to establish disease severity, follow progression, and evaluate response to treatment in clinical trials for this increasingly prevalent disease.

主权项

1. A method of determining the presence of fatty liver disease (FLD) in a patient, comprising:
providing a sample from a patient; measuring the level of coenzyme Q (CoQ) in the sample; and comparing the CoQ value from the patient with a threshold value, wherein if the CoQ value meets the threshold value the patient is determined to be at risk for fatty liver disease.