Disc annulus closure

摘要

Disclosed herein are methods for treating a defect in a spinal disc nuclear space, comprising: (a) creating an opening by open, percutaneous or laparoscopic techniques to access the defect in the nuclear space; (b) removing a desired amount of tissue from the nuclear space; (c) positioning a delivery catheter through the opening; (d) fluidically isolating the nuclear space by blocking the opening with a blocking component of the catheter; (e) delivering an in-situ curable liquid material through a lumen of the catheter to the nuclear space; and (f) maintaining the isolating until the liquid material has cured. Also disclosed are treatment systems and materials for prostheses.

主权项

1. A method for treating a defect in a spinal disc nuclear space, comprising:
(a) creating an opening by open, percutaneous or laparoscopic techniques to access the defect in the nuclear space; (b) removing a desired amount of tissue from the nuclear space; (c) positioning a delivery catheter through the opening; (d) fluidically isolating the nuclear space by blocking the opening with a blocking component of the catheter; (e) preparing an in-situ curable liquid material comprising a prepolymer comprising a polymeric polyol end-capped with diisocyanate, and a low molecular weight polyisocyanate; (f) delivering the in-situ curable liquid material through a lumen of the catheter to the nuclear space; and (g) curing the in-situ curable liquid material by adding an aqueous solution to the nuclear space.