| 发明名称 | Methods of stimulating protective immunity employing Dengue viral antigens | ||
| 摘要 | Compositions that include at least a portion of at least one pathogen-associated molecular pattern and at least a portion of at least one member selected from the group consisting of a Den1 viral envelope protein, a Den2 viral envelope protein, a Den3 viral envelope protein and a Den4 viral envelope protein are employed in methods to stimulate a protective immune response in a subject. | ||
| 申请公布号 | US8871221(B2) | 申请公布日期 | 2014.10.28 |
| 申请号 | US201314050938 | 申请日期 | 2013.10.10 |
| 申请人 | Vaxinnate Corporation | 发明人 | Powell Thomas J.;Nakaar Valerian;Song Langzhou;Huleatt James W.;McDonald William F.;Hewitt Duane D. |
| 分类号 | A61K39/295;C07K14/005;C07K14/255;A61K38/16;C07K14/245;A61K39/108;A61K39/112;A61K39/12 | 主分类号 | A61K39/295 |
| 代理机构 | Hamilton, Brook, Smith & Reynolds, P.C. | 代理人 | Hamilton, Brook, Smith & Reynolds, P.C. |
| 主权项 | 1. A method of stimulating an immune response in a subject, comprising the step of administering to the subject a composition that includes a non-glycosylated fusion protein comprising a portion of at least one flagellin and at least a portion of at least one Dengue viral envelope protein selected from the group consisting of a Den1 viral envelope protein, a Den2 viral envelope protein, a Den3 viral envelope protein and a Den4 viral envelope protein, wherein the portion of the flagellin is a Toll-like Receptor 5 agonist, the portion of the Dengue viral envelope protein is an antigen, and wherein the fusion protein activates Toll-like Receptor 5 and induces antibodies that neutralize a Dengue virus. | ||
| 地址 | Cranbury NJ US | ||