发明名称 Method for treating human diseases associated with an increased deoxyribonucleic acid content in extracellular spaces of tissues and a medicinal preparation for carrying out said method
摘要 The invention relates to medicine. The invention provides inventive method for treating human diseases associated with an increased deoxyribonucleic acid content in extracellular spaces of tissues and organs, which method comprises enterally administering DNAse enzyme in a quantity of 20 000-500 000 Kunz units in a day per 1 kg of the body mass. The single dose of the inventive medicinal preparation for treating human diseases associated with an increased deoxyribonucleic acid content in extracellular spaces of tissues and organs comprises 20 000-500 000 Kunz units of the DNAse enzyme. The oral administration of the above-mentioned important doses of the preparation allows the catalytically significant amount of DNAse to be absorbed into the systemic circulation in such a way that the dose-dependent treating effect thereof is exhibited.
申请公布号 US8871200(B2) 申请公布日期 2014.10.28
申请号 US200612516440 申请日期 2006.11.28
申请人 CLS Therapeutics Limited 发明人 Genkin Dmitry Dmitrievich;Tets Viktor Veniaminovich;Tets Georgy Viktorovich
分类号 A61K38/43;A61K38/46;A61K38/47;A61K9/00;A61K9/68;A61K9/20 主分类号 A61K38/43
代理机构 Troutman Sanders LLP 代理人 Troutman Sanders LLP
主权项 1. A method for treating a disease associated with increased deoxyribonucleic acid content in extracellular spaces of tissues and organs in a human in need thereof, said method comprising enterally administering to said human a DNASE I enzyme, wherein said enzyme is introduced in doses from 20 000 to 500 000 Kunitz units per 1 kg of the body mass per day.
地址 Guernsey, Channel Islands GB