Micro-RNA for the regulation of cardiac apoptosis and contractile function

摘要

The present invention relates to treating or preventing age-related cardiomyopathy by modulating the expression or activity of a miR-34 family member and/or PNUTS. Methods of treating or preventing age-related cardiomyopathy include administering an inhibitor of miR-34 expression or activity or an agonist of PNUTS expression or activity. Also provided herein are methods of treating or preventing cardiac fibrosis and myocardial infarction by administering an inhibitor of miR-34 expression or activity or an agonist of PNUTS expression or activity.

主权项

1. A method of treating acute myocardial infarction in a subject in need thereof comprising administering to the subject an inhibitor of a miR-34 family member, wherein the inhibitor of the miR-34 family member is an antisense oligonucleotide having a sequence that is at least partially complementary to a mature miR-34a sequence.