| 发明名称 | Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9) | ||
| 摘要 | Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described. | ||
| 申请公布号 | US8871914(B2) | 申请公布日期 | 2014.10.28 |
| 申请号 | US201414261063 | 申请日期 | 2014.04.24 |
| 申请人 | Amgen, Inc. | 发明人 | Jackson Simon Mark;Walker Nigel Pelham Clinton;Piper Derek Evan;Shen Wenyan;King Chadwick Terence;Ketchem Randal Robert;Mehlin Christopher;Carabeo Teresa Arazas |
| 分类号 | C07K16/40;C07K16/00;C12N15/113 | 主分类号 | C07K16/40 |
| 代理机构 | Knobbe, Martens, Olson & Bear, LLP | 代理人 | Knobbe, Martens, Olson & Bear, LLP |
| 主权项 | 1. An isolated human monoclonal antibody that binds to an epitope on PSCK9, wherein the epitope comprises at least one of amino acid residues S123, E129, A311, D313, or D337 of SEQ ID NO: 1, and wherein the monoclonal antibody blocks binding of PCSK9 to LDLR. | ||
| 地址 | Thousand Oaks CA US | ||