Azaindazole amide compounds as CCR1 receptor antagonists

摘要

Disclosed are CCR1 inhibitor compounds of the formula (I): which are useful in the treatment of autoimmune and other diseases. Also disclosed a pharmaceutical compositions containing the same, and methods of making and using same.;

主权项

1. A compound of the formula (I): wherein Ar is phenyl, naphthyl or heteroaryl chosen from aziridinyl, thienyl, furanyl, thiazolyl, isothiazolyl, isoxazolyl, oxazolyl, oxadiazolyl, pyrazolyl, thiadiazolyl, tetrazolyl, pyrrolyl, imidazolyl, pyrimidinyl, pyridinyl, pyrazinyl, pyridazinyl, pyranyl, benzofuranyl, indolyl, quinoxalinyl, benzimidazolyl, benzoxazolyl, benzothiazolyl, benzothienyl, quinolinyl, quinazolinyl, naphthyridinyl, indazolyl, triazolyl and purinyl each bearing from 0-4 substituents chosen from halogen, C1-5 alkyl, C3-7 cycloalkyl, C1-5 haloalkyl, cyano, nitro, —SR, —OR, —SO2R, —SO2NRR1, —NR1—SO2R, —CO2—R, —NRR1, —NR2C(O)—R, —C(O)NRR1, aryl ring and 5- or 6-membered heteroaryl ring each ring optionally substituted with 1 or 2 substituents chosen from halogen and C1-5 alkyl; R, R1, and, R2 are each independently hydrogen or C1-5 alkyl; X is halogen; or a pharmaceutically acceptable salt thereof.