| 发明名称 | Treating glaucoma, cardiovascular diseases, and renal diseases | ||
| 摘要 | This document provides methods and materials related to treating glaucoma, ocular hypertension, cardiovascular diseases, and renal diseases. For example, this document provides isolated nucleic acid molecules and viral vectors (e.g., lentiviral vectors) containing isolated nucleic acid molecules. Methods for reducing intraocular pressure as well as symptoms and progression of cardiovascular and renal diseases also are provided. | ||
| 申请公布号 | US8871733(B2) | 申请公布日期 | 2014.10.28 |
| 申请号 | US201213624383 | 申请日期 | 2012.09.21 |
| 申请人 | Mayo Foundation for Medical Education and Research | 发明人 | Poeschla Eric M.;Barraza Roman A. |
| 分类号 | A61K48/00;C12N9/02;A61K38/00 | 主分类号 | A61K48/00 |
| 代理机构 | Fish & Richardson P.C. | 代理人 | Fish & Richardson P.C. |
| 主权项 | 1. A method for treating a mammal having glaucoma or elevated intraocular pressure, said method comprising administering nucleic acid encoding a polypeptide having cyclooxygenase-2 activity and nucleic acid encoding a polypeptide having prostaglandin F2α receptor activity to an eye of said mammal under conditions effective to reduce intraocular pressure of said eye by at least 10 percent. | ||
| 地址 | Rochester MN US | ||