发明名称 |
Compositions and methods for treating AIDS or cancer by inhibiting the secretion of microparticles |
摘要 |
Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also disclosed is polynucleotide encoding the peptide, expression vectors carrying the polynucleotide, and methods for treating AIDS and tumors using the novel peptides. |
申请公布号 |
US8871708(B2) |
申请公布日期 |
2014.10.28 |
申请号 |
US201314015438 |
申请日期 |
2013.08.30 |
申请人 |
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发明人 |
Bond Vincent Craig;Powell Michael;Huang Ming Bo;Ali Syed;Raymond Andrea D.;Shelton Martin Neville;Villinger Francois Jean |
分类号 |
A61P31/12;A61P31/18;A61P35/00;A61K39/00;A61K39/21;C12N5/22;C07K7/06;C07K7/08;C07K14/005;A61K38/00 |
主分类号 |
A61P31/12 |
代理机构 |
Andrews Kurth LLP |
代理人 |
Wang Ping;Andrews Kurth LLP |
主权项 |
1. A peptide for inhibiting the release of microparticles in a cell, comprising:
a N-terminal; a C-terminal; and at least two VGFPV (SEQ ID NO: 1) motifs, wherein said peptide comprises the amino acid sequence of VGFPVAAVGFPV (SEQ ID NO: 2). |
地址 |
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