发明名称 |
Drug-delivery endovascular stent and method for treating restenosis |
摘要 |
A radially expandable, endovascular stent designed for placement at a site of vascular injury, for inhibiting restenosis at the site, a method of using, and a method of making the stent. The stent includes a radially expandable body formed of one or more metallic filaments and a liquid-infusible mechanical anchoring layer attached to or formed in outer surface of the filaments. A drug coating in the stent is composed of a substantially polymer-free composition of an anti-restenosis drug, and has a substratum infused in the anchoring layer and a substantially continuous surface stratum of drug that is brought into direct contact with the vessel walls at the vascular site. Thus, the rate of release of the anti-restenosis drug from the surface stratum into said vascular site is determined solely by the composition of said drug coating. |
申请公布号 |
US8871292(B2) |
申请公布日期 |
2014.10.28 |
申请号 |
US201213556893 |
申请日期 |
2012.07.24 |
申请人 |
Biosensors International Group, Ltd. |
发明人 |
Savage Douglas R.;Betts Ronald E. |
分类号 |
B05D3/12;B05D3/10;A61L33/00;A61F2/06;A61L31/16;A61F2/91 |
主分类号 |
B05D3/12 |
代理机构 |
Kilpatrick Townsend & Stockton LLP |
代理人 |
Kilpatrick Townsend & Stockton LLP |
主权项 |
1. A method of producing a radially expandable, endovascular stent designed for placement at a site of vascular injury, for inhibiting restenosis at the site, comprising applying a substantially polymer-free, liquid composition of an anti-restenosis drug to a radially expandable stent body formed of one or more metallic filaments defining an outer surface, and having attached thereto, a liquid-infusible mechanical anchoring layer having an average thickness of at least 3 μm, in an amount sufficient to infuse the composition into said anchoring layer, to form a drug coating substratum within the layer, and to form over the substratum, a substantially continuous surface stratum of drug, wherein the drug coating substratum constitutes 10 to 50% of the total composition of anti-restenosis drug and wherein the rate of release of the anti-restenosis drug from the surface stratum into said site of vascular injury is determined solely by the composition of said drug coating. |
地址 |
Hamilton BM |