Medical scaffold, methods of fabrication and using thereof

摘要

Articles of manufacturing comprising electrospun elements having continuous or stepwise gradients of porosity, average pore size, weight per volume and/or of agents for promoting cell colonization, differentiation, extravasation and/or migration are provided. Also provided are methods of manufacturing and using same for guiding tissue regeneration.

主权项

1. An article of manufacturing comprising an electrospun element having a continuous gradient of average pore size along at least a portion thereof, wherein said electrospun element comprises a single continuous fibrous filament.