发明名称 |
6-modificerede bicykliske nukleinsyreanaloger |
摘要 |
The present invention provides 6-modified bicyclic nucleoside analogs and oligomeric compounds comprising these nucleoside analogs. In preferred embodiments the nucleoside analogs have either ( R ) or ( S )-chirality at the 6-position. These bicyclic-nucleoside analogs are useful for enhancing properties of oligomeric compounds including nuclease resistance. |
申请公布号 |
DK2314594(T3) |
申请公布日期 |
2014.10.27 |
申请号 |
DK20100176867T |
申请日期 |
2007.01.27 |
申请人 |
ISIS PHARMACEUTICALS, INC |
发明人 |
SWAYZE, ERIC E.;SETH, PUNIT P. |
分类号 |
C07H19/04;A61K31/712;C07H21/00 |
主分类号 |
C07H19/04 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|