发明名称 |
Detektion og behandling af skizofreni |
摘要 |
<p>The present invention provides a method for diagnosing schizophrenia, and a schizophrenia diagnostic reagent or device for use in the method. The present invention further provides a therapeutic or ameliorating agent for schizophrenia, which is effective for the treatment or amelioration of schizophrenia. The therapeutic or ameliorating agent for schizophrenia contains a carbonyl scavenger or a carbonyl-modified protein formation inhibitor as an active ingredient. The method for diagnosing schizophrenia according to the present invention includes measuring at least one parameter in a subject, the parameter being selected from the group consisting of: (1) a genetic abnormality of glyoxalase I gene; (2) the expression level or activity of glyoxalase I in a biological sample; (3) the amount of a carbonyl compound or a carbonyl-modified protein that is a protein modified with the carbonyl compound; and (4) the amount of pyridoxal in a biological sample.</p> |
申请公布号 |
DK2189537(T3) |
申请公布日期 |
2014.10.27 |
申请号 |
DK20080792016T |
申请日期 |
2008.07.31 |
申请人 |
RENASCIENCE CO., LTD.;TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE |
发明人 |
MIYATA, TOSHIO;ARAI, MAKOTO;ITOKAWA, MASANARI |
分类号 |
C12Q1/68;A61K31/415;A61K31/4152;A61K31/437;A61K31/4415;A61K31/4439;A61K45/00;A61P25/18;C12N15/09;G01N30/88;G01N33/15;G01N33/50 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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