发明名称 |
Compuestos derivados de indazol-3-carboxamidas, como inhibidores de la ruta de señalizacion de wnt/b-catenina; composicion farmaceutica que los comprende; y su uso para el tratamiento de cancer, artritis reumatoide, infecciones micoticas y viricas, enfermedad de parkinson, un trastorno fibrotico, entre otras enfermedades. |
摘要 |
Indazole-3-carboxamide compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole-3-carboxamide compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states. |
申请公布号 |
CL2014000642(A1) |
申请公布日期 |
2014.10.24 |
申请号 |
CL20140000642 |
申请日期 |
2014.03.14 |
申请人 |
SAMUMED, LLC |
发明人 |
HOOD, JOHN;KC, SUNIL KUMAR |
分类号 |
C07D401/10;A61K31/4439;A61K31/4545;A61P19/02;A61P25/16;A61P31/10;A61P31/12;A61P35/00;C07D401/14;C07D405/14 |
主分类号 |
C07D401/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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