发明名称 |
DACH1 AS A BIOMARKER FOR DIABETES |
摘要 |
The present invention provides a method for assessing the presence and risk of developing type 2 diabetes or cardiovascular disease in a subject by detecting sequence variation in DACH1 (Dachshund homolog 1) gene. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for treating type 2 diabetes or cardiovascular disease in patients who have been tested and shown to have the pertinent genetic variations. |
申请公布号 |
US2014315198(A1) |
申请公布日期 |
2014.10.23 |
申请号 |
US201414209902 |
申请日期 |
2014.03.13 |
申请人 |
The Chinese University of Hong Kong ;Hospital Authority |
发明人 |
CHAN JULIANA CHUNG-NGOR;So Wing-Yee;Ma Ronald Ching-Wan |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
1. A method for assessing the presence or risk of type 2 diabetes, cancer, or cardiovascular disease in a subject, comprising the steps of:
(a) performing an assay that determines nucleotide sequence of at least a portion of genomic sequence of DACH1 (Dachshund homolog 1) present in a biological sample taken from the subject, and (b) comparing the sequence determined in step (a) with a corresponding standard sequence of DACH1, wherein a variation in the sequence determined in step (a) when compared with the standard sequence indicates that the subject has or is at risk of developing type 2 diabetes, cancer, or cardiovascular disease. |
地址 |
Shatin CN |