Glycosylated Polypeptide and Drug Composition Containing Said Polypeptide

摘要

[Problem] To provide a glycosylated polypeptide having affinity to somatostatin receptors and, compared to somatostatins, having improved in-blood stability. [Solution] The glycosylated polypeptide is characterized by at least two amino acids in a somatostatin or an analogue thereof being replaced by glycosylated amino acids.

主权项

1. A glycosylated polypeptide selected from the group consisting of:
(A) a SRIF14 consisting of the amino acid sequence of SEQ ID NO:1; (B) a polypeptide having one or a few amino acids deleted from, substituted with, or added to SRIF14, SRIF14 consisting of the amino acid sequence of SEQ ID NO:1; (C) a SRIF14 analog; (D) a polypeptide having 80% or more homology with SRIF14 consisting of the amino acid sequence of SEQ ID NO:1; (E) a polypeptide further comprising N amino acids at the N-terminal side of (A)-(D), wherein N is an integer from 1 or more to 20 or less; and (F) a polypeptide further comprising M amino acids at the C-terminal side of (A)-(D), wherein M is an integer from 1 or more to 6 or less; wherein at least two amino acids are substituted with a glycosylated amino acids, and the polypeptide has affinity towards somatostatin receptors.