METHOD OF MAKING BIOLOGICALLY ACTIVE ALPHA-BETA PEPTIDES

摘要

Described is a method of fabricating biologically active, unnatural polypeptides. The method includes the steps of selecting a biologically active polypeptide or biologically active fragment thereof having an amino acid sequence comprising α-amino acid residues, and fabricating a synthetic polypeptide that has an amino acid sequence that corresponds to the sequence of the biologically active polypeptide, but wherein about 14% to about 50% of the α-amino acid residues found in the biologically active polypeptide or fragment of step (a) are replaced with β-amino acid residues, and the α-amino acid residues are distributed in a repeating pattern.

主权项

1. A method of fabricating biologically active, unnatural polypeptides, the method comprising:
(a) selecting a biologically active polypeptide or biologically active fragment thereof having an amino acid sequence comprising α-amino acid residues; and (b) fabricating a synthetic polypeptide that has an amino acid sequence that corresponds to the sequence of the biologically active polypeptide or fragment of step (a), wherein
(i) in the synthetic polypeptide between about 14% and about 50% of the α-amino acid residues found in the biologically active polypeptide or fragment of step (a) are replaced with β-amino acid residues;(ii) in the synthetic polypeptide the β-amino acid residues and the α-amino acid residues are distributed in a repeating pattern; and(iii) the synthetic polypeptide has a length of from about 10 residues to about 100 residues and comprises at least two β-amino acid residues.