PHOTONIC BLOOD TYPING

摘要

Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.

主权项

1. A photonic device for determining blood type or immune sensitization to blood type, comprising:
a sample waveguide having a sample surface; and a binding coating covering and being in optical communication with at least a portion of the sample surface, the binding coating being configured to bind a target moiety indicative of blood type or immune sensitization to blood type, wherein the photonic device is configured such that light passed through the sample waveguide has an evanescent field that extends a distance beyond the sample waveguide sufficient to detect the target moiety indicative of blood type.