| 发明名称 |
METHODS OF TREATING CANCER |
| 摘要 |
The present invention provides methods of treating cancer, particularly cancers that are null or have decreased expression or activity of the Lkb1 gene. Also included are methods of identifying therapeutic targets for the treatment of cancer. |
| 申请公布号 |
US2014314791(A1) |
申请公布日期 |
2014.10.23 |
| 申请号 |
US201314370358 |
申请日期 |
2013.01.04 |
| 申请人 |
DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
Wong Kwok-Kin;Liu Yan |
| 分类号 |
C12N15/113;A61K45/06;A61K39/395;A61K31/55;G01N33/50;A61K31/407;A61K31/553;A61K31/497;A61K31/415;C07K16/40;A61K31/4535 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating a subject having a Lkb1 null cancer comprising
administering to said subject a compound that inhibits the expression of activity of deoxythymidylate kinase (DTYMK), checkpoint kinase 1 (CHEK1) or both. |
| 地址 |
Boston MA US |
