| 摘要 |
Provided are age-modified cells and method for making age modified cells using progerin or a progerin-like protein. The aging and/or maturation process can be accelerated and controlled for young and/or immature cells, such as a somatic cell, a stem cell, a stem cell-derived somatic cell, including an induced pluripotent stem cell-derived cell, by contacting with progerin or a progerin-like protein. Methods described by the present disclosure can produce age- appropriate cells from a somatic cell or a stem cell, such as an old cell and/or a mature cell. Such age- modified cells constitute model systems for the study of late-onset diseases and/or disorders. |
