| 摘要 |
The application is directed to a method and apparatus for analyzing a target material, eg. DNA, based on monitoring changes in electrical properties on translocation of the target through a nanopore in a constricted 2D material such as graphene. In a preferred embodiment, the apparatus comprises a monolayer graphene quantum point contact (g-QPC) device containing a single layer of patterned graphene connected to source and drain electrodes and sandwiched between two oxide layers to isolate the graphene from the aqueous environment. The graphene and oxide layers have coaxial nanopores ranging from 2 to 4 nm to allow passage of the target. A back gate underneath the lower oxide substrate, made of metal, heavily doped semiconductor, or another graphene layer, controls the charge carrier concentration and enhances the electrical sensitivity of the device to DNA translocation. Additional embodiments are disclosed. |
