ANTIDOTES FOR FACTOR Xa INHIBITORS AND METHODS OF USING THE SAME IN COMBINATION WITH BLOOD COAGULATING AGENTS

摘要

PROBLEM TO BE SOLVED: To provide improved antidotes that are effective and efficient in substantially neutralizing the anticoagulant activity of an fXa inhibitor, as well as in initiating the coagulation process in the event of an overdose of the fXa inhibitor.SOLUTION: The invention relates to the methods of using a factor Xa (fXa) derivative in combination with a blood coagulating agent to prevent or reduce bleeding in a subject undergoing anticoagulant therapy with a factor Xa inhibitor. The invention also relates to compositions comprising the fXa derivative and the blood coagulating agent. The fXa derivative has reduced or no intrinsic procoagulant activity, is capable of binding and/or neutralizing fXa inhibitors, and does not assemble into a prothrombinase complex. The blood coagulating agent has procoagulant, anti-thrombolytic, and/or anti-fibrinolytic activity.