| 摘要 |
<p>PURPOSE: A pharmaceutical composition containing bee venom as an active ingredient for preventing and treating respiratory inflammation is provided to effectively suppress inflammation in the respiratory epithelial cells, caused by fungi and dust mites and to effectively prevent nasal cavity inflammation in an animal model with allergic rhinitis. CONSTITUTION: Bee venom prevents and treats respiratory inflammation and is freeze-dried for intranasal administration. A pharmaceutical composition for preventing and treating respiratory inflammation contains 0.00005-1 ug/ml of bee venom as an active ingredient. A method for determining the recommended dosage of a drug for preventing and treating respiratory inflammation comprises the steps of: isolating bee venom from Apis mellifera L. and freeze-drying the bee venom; applying the freeze-dried bee venom to nasal mucosal endothelial cells in various concentrations to measure the efficacy of the bee venom; treating an animal model with allergic rhinitis with the freeze-dried bee venom in various concentrations; and measuring treatment index and numerical value in respiratory inflammation by a conventional experimental method using blood and nasal cavity tissues collected from an experimental animal treated with the freeze-dried bee venom and determining the recommended dosage.</p> |
