| 主权项 |
1. A method of blocking a transient receptor potential vanilloid 1 (TRPV1) in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a compound represented by Formula IV: wherein: Z is an A-G(=K)-X-Y group, and wherein: A is alkyl or absent; G is selected from the group consisting of C, S and PRa; K is selected from the group consisting of O and S; X is selected from the group consisting of NRb, O, S or absent; and Y is selected from the group consisting of hydrogen, alkyl, hydroxyalkyl, cycloalkyl, heteroalicyclic, aryl and a polyalkylene glycol residue, R1 is selected from the group consisting of hydrogen, alkyl, cycloalkyl or aryl; each of R2, R3, R4, R5, R6, R7, R8, R9 and R10 is independently selected from the group consisting of hydrogen, alkyl, hydroxyalkyl, trihaloalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroalicyclic, halo, hydroxy, alkoxy, aryloxy, thiohydroxy, thioalkoxy, thioaryloxy, sulfinyl, sulfonyl, cyano, nitro, an electron-withdrawing group, amino and —NR15R16, or, alternatively, at least two of R2, R3, R4, R5 and R6, of R7, R8, R9 and R10 form a five- or six-membered aromatic, heteroaromatic, alicyclic or heteroalicyclic ring; R15 and R16 are each independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, carbonyl and sulfonyl, or, alternatively R15 and R16 form a five- or six-member heteroalicyclic ring; and each of said Ra and Rb is selected from the group consisting of hydrogen, alkyl, cycloalkyl and aryl. |
