COATED MESOPOROUS NANOPARTICLES

摘要

Provided are methods for producing mesoporous nanoparticles that can, once loaded, retain small or large molecules (e.g., molecules having a molecular weight that is less or greater than about 900 Da) until release is desired, upon which time the mesoporous nanoparticles can release the loaded molecule in a controlled manner for a desired period of time, including an extended period of time. Also disclosed are methods for treating a subject comprising administering to the subject a mesoporous nanoparticle according to the present disclosure.

主权项

1. A nanoparticle comprising:
an inorganic material comprising a plurality of pores of which at least 50% have a diameter of 3.0 to 4.5 nm; and, a coating comprising a biocompatible polymer on said inorganic material, at least some of said pores being loaded with a molecule having a molecular weight that is at least about 900 Da.