| 发明名称 |
METHOD OF TREATING ALVEOLAR BONE LOSS THROUGH THE USE OF ANTI-SCLEROSTIN ANTIBODIES |
| 摘要 |
The invention provides a method of treating alveolar bone loss involving administration of a sclerostin inhibitor to a subject in need thereof. |
| 申请公布号 |
US2014314776(A1) |
申请公布日期 |
2014.10.23 |
| 申请号 |
US201214362322 |
申请日期 |
2012.12.11 |
| 申请人 |
AMGEN, INC. ;THE REGENTS OF THE UNIVERSITY OF MICHIGAN |
发明人 |
Ke Hua Zhu;Liu Min;Giannobile William V. |
| 分类号 |
C07K16/18;A61K45/06;A61K39/395 |
主分类号 |
C07K16/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treating alveolar bone loss in a subject comprising administering to the subject an anti-sclerostin antibody in an amount effective to decrease the distance between the cement-enamel junction and the alveolar bone crest, at a dose from about 5 mg to about 1,000 mg per week. |
| 地址 |
Thousand Oaks CA US |
