CLOSTRIDIUM DIFFICILE LIPOTEICHOIC ACID AND USES THEREOF

摘要

A novel lipoteichoic acid (LTA) was isolated from C. difficile, the structure of which is illustrated below wherein n is an integer between 1 and 20, R3 and R4 are independently selected from C 14:0, C 16:0, C 16:1, C 18:0 or C18:1 fatty acid or any combination thereof wherein one of COR3 or COR4 may be replaced by H. Further described are conjugates comprising the novel LTA and vaccines produced using the isolated LTA and the LTA conjugates. The invention also encompasses methods of conferring immunity against C. difficile comprising administering a vaccine of the invention, and methods of detecting C. difficile using the isolated LTA of the invention.

主权项

1. An isolated LTA comprising a structure of Formula Iwherein R1 is selected from NH2 and NHAc; each R2 is independently selected from NH2 and NHAc; and n is an integer between about 1 and 20.