发明名称 |
MULTIVALENT PNEUMOCOCCAL POLYSACCHARIDE-PROTEIN CONJUGATE COMPOSITION |
摘要 |
An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F) conjugated to a carrier protein. The immunogenic composition, formulated as a vaccine, increases coverage against pneumococcal disease in infants and young children globally, and provides coverage for serotypes 6A and 19A that is not dependent on the limitations of serogroup cross-protection. |
申请公布号 |
US2014314805(A1) |
申请公布日期 |
2014.10.23 |
申请号 |
US201414322057 |
申请日期 |
2014.07.02 |
申请人 |
Wyeth LLC |
发明人 |
Hausdorff William P.;Siber George Rainer;Paradiso Peter R. |
分类号 |
A61K39/385;A61K39/39;A61K39/09 |
主分类号 |
A61K39/385 |
代理机构 |
|
代理人 |
|
主权项 |
1. A multivalent immunogenic composition comprising polysaccharide-protein conjugates and a physiologically acceptable vehicle, wherein each of the conjugates comprises a capsular polysaccharide from a different serotype of Streptococcus pneumoniae conjugated to a carrier protein, wherein the serotypes comprise 4, 6B, 9V, 14, 18C, 19F, 23F and at least one additional serotype, wherein the additional serotype is serotype 3, and wherein the carrier protein is CRM197. |
地址 |
Madison NJ US |