| 摘要 |
[Problem] Unit sugars located at the reducing end of a sugar chain undergo ring-opening and produce an α-anomer/&bgr;-anomer mixture during introduction of amino groups to the reducing end of the sugar chain by the conventional technique of the ammonium carbonate method when a sugar-chain compound having an activating group is produced. [Solution] Provided is a method comprising: cutting a sugar chain from a sugar-chain peptide so as to keep a nitrogen atom derived from an asparagine side chain bonded to the reducing end of the sugar chain, using as the raw material a compound having a sugar-chain asparagine structure; introducing an activating group to the nitrogen atom while maintaining not only a covalent bond between the reducing end of the sugar chain and the nitrogen atom, but also a &bgr;-configuration; and producing a sugar-chain compound having an activating group and high &bgr; selectivity. Also provided is a novel sugar-chain compound having an activating group and being a &bgr;-anomer, as a compound of the invention. |
