| 发明名称 |
METHODS AND COMPOSITIONS FOR THE SPECIFIC INHIBITION OF MET BY DOUBLE STRANDED RNA |
| 摘要 |
This invention relates to compounds, compositions, and methods useful for reducing MET target RNA and protein levels via use of dsRNAs, e.g., Dicer substrate siRNA (DsiRNA) agents. |
| 申请公布号 |
US2014315983(A1) |
申请公布日期 |
2014.10.23 |
| 申请号 |
US201214356051 |
申请日期 |
2012.10.25 |
| 申请人 |
Dicema Pharmaceuticals, Inc. |
发明人 |
Brown Bob D.;Dudek Henryk T. |
| 分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. An isolated double stranded nucleic acid (dsNA) comprising first and second nucleic acid strands comprising RNA, wherein said first strand is 15-35 nucleotides in length and said second strand of said dsNA is 19-35 nucleotides in length, wherein said second oligonucleotide strand is sufficiently complementary to a target MET mRNA sequence selected from Table 15 along at least 19 nucleotides of said second oligonucleotide strand length to reduce MET target mRNA expression when said double stranded nucleic acid is introduced into a mammalian cell. |
| 地址 |
Watertown MA US |
