| 发明名称 |
INHIBITION OF DNA DAMAGE REPAIR BY ARTIFICIAL ACTIVATION OF PARP WITH OLIGONUCLEOTIDE MOLECULES |
| 摘要 |
<p>The present application relates to a new class of PARP inhibitors and their uses as a drug, especially as for use in a cancer therapy. These new PARP inhibitors include a double stranded portion with a nick or a gap on one strand and the tethered 5' and 3' ends of two extremities of the double stranded portion.</p> |
| 申请公布号 |
WO2014170441(A1) |
申请公布日期 |
2014.10.23 |
| 申请号 |
WO2014EP57904 |
申请日期 |
2014.04.17 |
| 申请人 |
DNA THERAPEUTICS;INSTITUT CURIE |
发明人 |
DUTREIX, MARIE;SUN, JIAN-SHENG |
| 分类号 |
C12N15/11;A61K31/712;A61P35/00 |
主分类号 |
C12N15/11 |
| 代理机构 |
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代理人 |
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