发明名称 |
CARBOXYLIC ACID DERIVATIVES COMPRISING FOUR CYCLES ACTING AS GLP-1 RECEPTOR MODULATORS FOR THERAPY OF DISEASES SUCH AS DIABETES |
摘要 |
<p>The invention relates to compounds that modulate the glucagon-like peptide 1 (GLP-1) receptor, methods of their synthesis, and methods of their therapeutic and/or prophylactic use. Such compounds are act as modulators or potentiators of GLP-1 receptor on their own, or with receptor ligands including GLP-1 peptides GLP-1(7-36) and GLP-1(9-36), or with peptide-based therapies, such as exenatide and liraglutide, and have the following general structure (where“”represents either or both the R and S form of the compound): where A, B, C, Y1, Y2, Z, R1, R2, R3, R4, R5, W1, n, p and q are as defined herein.</p> |
申请公布号 |
EP2791112(A2) |
申请公布日期 |
2014.10.22 |
申请号 |
EP20120806828 |
申请日期 |
2012.12.12 |
申请人 |
RECEPTOS, INC. |
发明人 |
BOEHM, MARCUS, F.;MARTINBOROUGH, ESTHER;MOORJANI, MANISHA;TAMIYA, JUNKO;HUANG, LIMING;YEAGER, ADAM, R.;BRAHMACHARY, ENUGURTHI;FOWLER, THOMAS;NOVAK, ANDREW;MEGHANI, PREMJI;KNAGGS, MICHAEL |
分类号 |
C07D211/22;A61K31/433;A61P3/10;C07D233/54;C07D233/60;C07D239/26;C07D239/34;C07D241/08;C07D255/02;C07D263/32;C07D271/06;C07D271/107;C07D277/24;C07D285/12;C07D401/04;C07D403/04;C07D403/12;C07D409/12;C07D413/04;C07D417/12;C07D495/04 |
主分类号 |
C07D211/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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