摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a method for producing 6-bromo-N-methyl-2-naphthamide more economically and efficiently. <P>SOLUTION: In this method for producing 6-bromo-N-methyl-2-naphthamide by mixing a first liquid containing 6-bromo-2-naphthoic acid chloride with a second liquid containing monomethylamine and a trapping agent of hydrogen chloride, the second liquid contains an amide-based solvent, and the amide-based solvent does not contain N, N-dimethylformamide. Preferably, the trapping agent of hydrogen chloride comprises alkaline aqueous solution, or water is further added to a liquid obtained by mixing the first liquid with the second liquid. <P>COPYRIGHT: (C)2012,JPO&INPIT</p> |