发明名称 |
ALPHA-AMINOAMIDINE POLYMERS AND USES THEREOF |
摘要 |
<p>α-Aminoamidine polymers and methods of preparing a-aminoamidine polymers by reacting by reacting one or more amines with one or more isocyanides and one or more aldehydes are described. Methods of preparing a-aminoamidine polymers from commercially available starting materials are also provided, wherein the starting materials are racemic or stereochemically pure. a-Aminoamidine polymers or salt forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems and for other purposes as well such as, for example, coatings, additives, excipients, plastics, and materials, etc. Given the amino moiety of theseα-aminoamidine polymers, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventiveα-aminoamidine polymers and polynucleotides can be prepared. The inventiveα-aminoamidine polymers may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.</p> |
申请公布号 |
EP2791210(A1) |
申请公布日期 |
2014.10.22 |
申请号 |
EP20120809954 |
申请日期 |
2012.12.15 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
VEGAS, ARTURO, JOSE;WHITEHEAD, KATHRYN, ANN;ANDERSON, DANIEL, GRIFFITH;LANGER, ROBERT, S.;DORKIN, JOSEPH, R. |
分类号 |
C08G73/00;A61K9/127;A61K9/51;A61K47/34;C08L79/00;C12N15/88 |
主分类号 |
C08G73/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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