发明名称 |
COMPOUNDS AND COMPOSITIONS FOR STABILIZING HYPOXIA INDUCIBLE FACTOR-2 ALPHA AS A METHOD FOR TREATING CANCER |
摘要 |
Disclosed herein is {[5-(3-fluorophenyl)-3-hydroxypyridine-2-carbonyl]-amino}acetic acid and the ester and amide prodrugs thereof, that can stabilize hypoxia inducible factor-2 alpha (HIF-2α) and thereby provide a method for treating cancer. Further disclosed are compositions which comprise {[5-(3-fluorophenyl)-3-hydroxypyridine-2-carbonyl]-amino}acetic acid and/or a prodrug thereof which can be used to treat cancer. |
申请公布号 |
EP2717870(A4) |
申请公布日期 |
2014.10.22 |
申请号 |
EP20120796395 |
申请日期 |
2012.06.05 |
申请人 |
AKEBIA THERAPEUTICS INC. |
发明人 |
SHALWITZ, ROBERT;GARDNER, JOSEPH, H.;JANUSZ, JOHN, M. |
分类号 |
A61K31/195;A61K31/4412;A61P35/00;C07D213/81 |
主分类号 |
A61K31/195 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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