TARGETED FREQUENCY MULTIPLE PATH LENGTH MIXERS

摘要

Mixers in microfluidic separation systems comprise multiple fluidic paths that extend from a distribution well to a mixing well. An incoming flow of solvent composition splits at the distribution well into as many streams as fluidic paths. The streams recombine at the mixing well to produce an output stream. One embodiment has fluidic paths with different dwell volumes that determine a percentage of the incoming flow flowing through each path. These dwell volumes can be targeted to attenuate a known noise characteristic in the incoming compositional flow. Another embodiment of mixer has a contoured surface disposed between the distribution and mixing wells. The paths extend from the distribution well to the mixing well through this contoured surface, each path passing through a different valley defined by opposing upwardly sloping banks. The valleys can have different dwell volumes that determine a percentage of the incoming compositional flow flowing through each valley.