Substituted heterocycles and their use as allosteric modulators of nicotinic and GABA_Areceptors

摘要

The present invention is related to heterocycles represented by a compound of Formula I that are novel allosteric modulators of α7 nAChRs and/or GABAA receptors. The invention also discloses the treatment of disorders that are responsive to enhancement of acetylcholine action on α7 nAChRs and negative allosteric modulation of GABAA receptors in a mammal by administering an effective amount of a compound of Formula I.;

主权项

1. A compound of Formula I:or a pharmaceutically acceptable salt thereof, wherein:
n is 1-5; R1 is selected from the group consisting of hydrogen, unsubstituted or substituted alkyl and unsubstituted or substituted cycloalkyl; each R2 is independently selected from the group consisting of hydrogen, fluoro, chloro, bromo, iodo, C1-10alkoxy, nitro, haloC1-10alkyl, perhaloC1-10alkyl and unsubstituted or substituted C1-10alkyl; A, E and F are independently selected from the group consisting CR3 and nitrogen; B is nitrogen; G and D are each carbon; each R3 is independently selected from the group consisting of hydrogen and unsubstituted or substituted alkyl; and R4, R5 and R6 are independently selected from the group consisting of hydrogen and unsubstituted or substituted alkyl.