| 摘要 |
Benzimidazoles having inhibitory activity on RSV replication and having the formula;
the prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof, compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions. |
| 主权项 |
1. A compound represented by formula I, a prodrug, N-oxide, addition salt, quaternary amine, metal complex, or a stereochemically isomeric form thereof; wherein each X independently is C or N; R1 is H; R2 is selected from the group consisting of Br and Cl; R3 is —(CR6R7)n—R8; R4 is selected from the group consisting of H, C3-C7cycloalkyl, C2-C10 alkenyl, —(CR6R7)n—R8; —CH2-p-Fluorophenyl, CH2CF3 and —SO2CH3; R5 is present where X is C, whereby each R5 is selected, each independently, from the group consisting of H, C1-C6alkyl, C1-C6alkoxy, halogen, and CN; R5 is absent where X is N; R6 and R7 are H; R8 is selected from the group consisting of H, OH, CF3, CHF2, F, Cl, SO2CH3, SO2C3-C7cycloalkyl, NR6SO2R6, SO2NR6R7, NR6SO2C3-C7cycloalkyl, CN, NR6R7, COOH, COOR6, CONR6R7, OCOC1-C6alkyl, CONR6SO2R7, CONH—R6—SO2R7, CONH—R6—SO2NR6R7CONR6SO2NR6R7, phtalimido or a 5 to 6 membered aliphatic or aromatic ring that optionally contains one or more heteroatoms selected from the group N, S, O; n is an integer having a value from 1 to 6. |
