| 主权项 |
1. A compound of the formula I wherein A is selected from the group Aa consisting of
a heteroaryl group with 5 or 6 ring atoms containing one to three heteroatoms independently selected from N, O, S,
wherein above mentioned heteroaryl groups may optionally be substituted with 1 or 2 substituents independently selected from the group consisting of halogen, cyano, C1-6-alkyl-, HO—C1-6-alkyl-, which is optionally fluorinated with 1 to 13 fluorine atoms, C3-6-cycloalkyl-, C1-4-alkyl-O—C1-3-alkyl-, C1-4-alkyl-O— which is optionally fluorinated with 1 to 9 fluorine atoms and (C1-4-alkyl)3Si—; B is selected from the group Ba consisting of wherein above mentioned phenyl-, pyridinyl-, pyrimidinyl-, pyridazinyl and pyrazinyl groups may optionally be substituted with 1 or 2 substituents independently selected from the group consisting of HO—, halogen, cyano, C1-6-alkyl- which is optionally fluorinated with 1 to 13 fluorine atoms, C3-6-cycloalkyl-O— and C1-6-alkyl-O— which is optionally fluorinated with 1 to 13 fluorine atoms; D is selected from the group Da consisting of
a 4- to 12-membered mono-, bicyclic or bridged heterocyclyl group, or a 3- to 12-membered mono- or bicyclic carbocyclyl group,
wherein above mentioned group Da may optionally be substituted with 1 to 4 substituents independently selected from the group consisting of halogen, cyano, C1-6-alkyl- which is optionally fluorinated with 1 to 13 fluorine atoms, C3-6-cycloalkyl-, heterocyclyl, aryl, aryl-C1-3-alkyl-, heteroaryl, heteroaryl-C1-3-alkyl-, HC(O)—, C1-6-alkyl-C(O)—, C3-6-cycloalkyl-C(O)—, aryl-C(O)—, C1-4-alkyl-O—C(O)—, (C1-4-alkyl)2N—C(O)—, HO—, oxo, C1-6-alkyl-O— which is optionally fluorinated with 1 to 13 fluorine atoms, C3-6-cycloalkyl-O—, heterocyclyl-O—, aryl-O—, heteroaryl-O—, H2N—, (C1-4-alkyl)2N—, azetidinyl, pyrrolidinyl and (C1-4-alkyl)(C1-3-alkyl-C(O))N—,
wherein above mentioned aryl-C(O)—, aryl-O—, aryl, aryl-C1-3-alkyl-, heteroaryl, heteroaryl-C1-3-alkyl- and heteroaryl-O— groups may optionally be substituted with 1 to 3 substituents independently selected from the group consisting of HO—, C1-4-alkyl-O—, F3CO—, F3C—, F2HCO—, FH2CO—, heterocyclyl-O—, cyano, halogen, F5S—, (C1-4-alkyl)3Si—, nitro, H2N—, (C1-4-alkyl)2N—, (H2N)—C(O)—, (C1-4-alkyl)-HN—C(O)—, (C1-4-alkyl)2N—C(O)—, C1-4-alkyl-O—C1-4-alkyl- and C1-6-alkyl- which is optionally fluorinated with 1 to 13 fluorine atoms; W is selected from the group Wa consisting of
—(R7)N— and —O—; R1 is selected from the group R1a consisting of
H, C1-8-alkyl-, C2-8-alkenyl-, C2-8-alkynyl-, carbocyclyl, carbocyclyl-C1-3-alkyl-, C-linked heterocyclyl, heterocyclyl-C1-3-alkyl-, aryl, aryl-C1-3-alkyl-, heteroaryl, heteroaryl-C1-3-alkyl-, R4R5N—C1-3-alkyl-, R4O—, R4S(O)m— with m=0, 1, 2,
wherein above mentioned C1-8-alkyl-, C2-8-alkenyl-, C2-8-alkynyl-, carbocyclyl, carbocyclyl-C1-3-alkyl-, C-linked heterocyclyl, heterocyclyl-C1-3-alkyl-, aryl, aryl-C1-3-alkyl-, heteroaryl, heteroaryl-C1-3-alkyl- and R4R5N—C1-3-alkyl- groups may optionally be substituted with 1 to 3 substituents independently selected from the group consisting of HO—, oxo, C1-4-alkyl-O—, C3-6-cycloalkyl-O—, heterocyclyl-O—, cyano, halogen, F5S—, (C1-4-alkyl)3Si—, nitro, H2N—, (C1-4-alkyl)2N—, (H2N)—C(O)—, (C1-4-alkyl)-C(O)—, (C1-4-alkyl)-O—C(O)—, (C1-4-alkyl)-HN—C(O)—, (C1-4-alkyl)2N—C(O)—, C1-4-alkyl-O—C1-4-alkyl- and C1-6-alkyl-, and
wherein above mentioned C1-4-alkyl-O—, C3-6-cycloalkyl-O—, heterocyclyl-O—, (C1-4-alkyl)2N—, (C1-4-alkyl)-C(O)—, (C1-4-alkyl)-O—C(O)—, (C1-4-alkyl)-HN—C(O)—, (C1-4-alkyl)2N—C(O)—, C1-4-alkyl-O—C1-4-alkyl- and C1-6-alkyl- groups may optionally be substituted with 1 to 13 fluorine atoms; R2 is selected from the group R2a consisting of
H, C1-8-alkyl-, C2-8-alkenyl-, C2-8-alkynyl-, carbocyclyl, carbocyclyl-C1-3-alkyl-, C-linked heterocyclyl, heterocyclyl-C1-3-alkyl-, aryl, aryl-C1-3-alkyl-, heteroaryl, heteroaryl-C1-3-alkyl-, R4R5N—, R4R5N—C1-3-alkyl-, R4R5N—C(O)— and R4O—,
wherein above mentioned C1-8-alkyl-, C2-8-alkenyl-, C2-8-alkynyl-, carbocyclyl, carbocyclyl-C1-3-alkyl-, C-linked heterocyclyl, heterocyclyl-C1-3-alkyl-, aryl, aryl-C1-3-alkyl-, heteroaryl and heteroaryl-C1-3-alkyl-groups may optionally be substituted with 1 to 3 substituents independently selected from the group consisting of HO—, oxo, C1-4-alkyl-O—, C3-6-cycloalkyl-O—, heterocyclyl-O—, cyano, halogen, F5S—, (C1-4-alkyl)3Si—, nitro, H2N—, (C1-4-alkyl)2N—, (H2N)—C(O)—, (C1-4-alkyl)-C(O)—, (C1-4-alkyl)-O—C(O)—, (C1-4-alkyl)-HN—C(O)—, (C1-4-alkyl)2N—C(O)—, C1-4-alkyl-O—C1-4-alkyl-, C3-5-cycloalkyl- and C1-6-alkyl-, and
wherein above mentioned C1-4-alkyl-O—, C3-6-cycloalkyl-O—, heterocyclyl-O—, (C1-4-alkyl)2N—, (C1-4-alkyl)-C(O)—, (C1-4-alkyl)-O—C(O)—, (C1-4-alkyl)-HN—C(O)—, (C1-4-alkyl)2N—C(O)—, C1-4-alkyl-O—C1-4-alkyl-, C3-5-cycloalkyl- and C1-6-alkyl- may optionally be substituted with 1 to 13 fluorine atoms; R3 is selected from the group R3a consisting of
H, C1-8-alkyl-, C2-8-alkenyl-, C2-8-alkynyl-, carbocyclyl, carbocyclyl-C1-3-alkyl-, C-linked heterocyclyl, heterocyclyl-C1-3-alkyl-, aryl, aryl-C1-3-alkyl-, heteroaryl, heteroaryl-C1-3-alkyl-, R4R5N—, R4R5N—C1-3-alkyl-, and R4O—,
wherein above mentioned C1-8-alkyl-, C2-8-alkenyl-, C2-8-alkynyl-, carbocyclyl, carbocyclyl-C1-3-alkyl-, C-linked heterocyclyl, heterocyclyl-C1-3-alkyl-, aryl, aryl-C1-3-alkyl-, heteroaryl and heteroaryl-C1-3-alkyl-groups may optionally be substituted with 1 to 3 substituents independently selected from the group consisting of HO—, oxo, C1-4-alkyl-O—, C3-6-cycloalkyl-O—, heterocyclyl-O—, cyano, halogen, F5S—, (C1-4-alkyl)3Si—, nitro, H2N—, (C1-4-alkyl)2N—, (H2N)—C(O)—, (C1-4-alkyl)-C(O)—, (C1-4-alkyl)-O—C(O)—, (C1-4-alkyl)-HN—C(O)—, (C1-4-alkyl)2N—C(O)—, C1-4-alkyl-O—C1-4-alkyl- and C1-6-alkyl-, and
wherein above mentioned C1-4-alkyl-O—, C3-6-cycloalkyl-O—, heterocyclyl-O—, (C1-4-alkyl)2N—, (C1-4-alkyl)-C(O)—, (C1-4-alkyl)-O—C(O)—, (C1-4-alkyl)-HN—C(O)—, (C1-4-alkyl)2N—C(O)—, C1-4-alkyl-O—C1-4-alkyl- and C1-6-alkyl- groups may optionally be substituted with 1 to 13 fluorine atoms; R4, R5 are selected independently of each other from the group R4a/R5a consisting of
H, C1-6-alkyl-, carbocyclyl, carbocyclyl-C1-3-alkyl-, carbocyclyl-O—C2-4-alkyl-, heterocyclyl, heterocyclyl-C1-6-alkyl-, heterocyclyl-O—C2-4-alkyl-, aryl, aryl-C1-3-alkyl-, aryl-O—C2-3-alkyl-, heteroaryl, heteroaryl-C1-3-alkyl- and heteroaryl-O—C2-3-alkyl-,
wherein above mentioned C1-6-alkyl-, carbocyclyl, carbocyclyl-C1-3-alkyl-, carbocyclyl-O—C2-4-alkyl-, heterocyclyl, heterocyclyl-C1-6-alkyl- or heterocyclyl-O—C2-4-alkyl- groups may optionally be substituted with 1 to 3 substituents independently selected from the group consisting of halogen, cyano, HO—, oxo, C1-4-alkyl-O— which is optionally fluorinated with 1 to 9 fluorine atoms, C1-4-alkyl-O—C(O)—, HO—C1-4-alkyl-, C1-4-alkyl-O—C1-4-alkyl-, heterocyclyl, (C1-4-alkyl)2N—, (C1-3-alkyl)2N—C(O)—, and C1-6-alkyl- which is optionally fluorinated with 1 to 13 fluorine atoms,wherein above mentioned aryl-, aryl-C1-3-alkyl-, aryl-O—C2-3-alkyl-, heteroaryl-, heteroaryl-C1-3-alkyl- and heteroaryl-O—C2-3-alkyl- groups may optionally be substituted with 1 to 3 substituents independently selected from the group consisting of HO—, C1-4-alkyl-O—, F3CO—, F2HCO—, FH2CO—, heterocyclyl-O—, cyano, halogen, F5S—, (C1-4-alkyl)3Si—, nitro, (R6)2N—, (H2N)—C(O)—, (C1-4-alkyl)-HN—C(O)—, (C1-4-alkyl)2N—C(O)—, C1-4-alkyl-O—C1-4-alkyl- and C1-6-alkyl- which is optionally fluorinated with 1 to 13 fluorine atoms, orR4a and R5a form together with the nitrogen atom to which they are attached a 4-12-membered mono-, bicyclic or bridged ring system optionally containing one or two double bonds and/or one aromatic ring and optionally containing one or two additional heteroatoms selected from the group consisting of —O—, —S—, —S(O)—, —S(O)2—, —N(R6)—,
wherein 2 geminal hydrogen atoms of the 4-12-membered mono- or bicyclic ring system may be replaced by a —(CH2)1-5— group and
wherein one —(CH2)— group of the —(CH2)1-5— group may be replaced by —O— or —N(R6)— andwherein above mentioned 4-12-membered mono-, bicyclic or bridged ring system may optionally be substituted with 1 or 2 substituents independently selected from the group consisting of halogen, cyano, aryl, heteroaryl, aryl-C1-3-alkyl-, C1-6-alkyl- which is optionally fluorinated with 1 to 13 fluorine atoms, heterocyclyl, HO—, oxo, C1-6-alkyl-O—, C3-6-cycloalkyl-O—, C1-4-alkyl-O—C(O)—, HO—C1-4-alkyl-, C1-4-alkyl-O—C1-4-alkyl-, C3-6-cycloalkyl-O—C1-4-alkyl-, heterocyclyl-O—, heterocyclyl-O—C1-4-alkyl-, aryl-O—, heteroaryl-O— and (R6)2N—,
wherein the directly above mentioned aryl, aryl-C1-3-alkyl-, aryl-O—, heteroaryl-O—, and heteroaryl groups may optionally be substituted with 1 to 3 substituents independently selected from the group consisting of HO—, C1-4-alkyl-O—, F3CO—, F2HCO—, FH2CO—, heterocyclyl-O—, cyano, halogen, F5S—, (C1-4-alkyl)3Si—, nitro, amino, (C1-4-alkyl)2N—, (H2N)—C(O)—, (C1-4-alkyl)-HN—C(O)—, (C1-4-alkyl)2N—C(O)—, C1-4-alkyl-O—C1-4-alkyl- and C1-6-alkyl- which is optionally fluorinated with 1 to 13 fluorine atoms; R6 is selected independently of each other from the group R6a consisting of
H, C1-6-alkyl-, C3-6-cycloalkyl, heterocyclyl, heteroaryl, HC(O)—, C1-6-alkyl-C(O)—, C3-6-cycloalkyl-C(O)—, aryl-C(O)—, C1-4-alkyl-O—C(O)— and (C1-4-alkyl)2N—C(O)—,
wherein above mentioned C1-6-alkyl-, C3-6-cycloalkyl-, C1-6-alkyl-C(O)— and C3-6-cycloalkyl-C(O)— groups may optionally be substituted with 1-13 fluorine atoms,wherein the above mentioned aryl-C(O)— and heteroaryl group may optionally be substituted with 1 to 3 substituents independently selected from the group consisting of HO—, C1-4-alkyl-O—, F3CO—, F2HCO—, FH2CO—, heterocyclyl-O—, cyano, halogen, F5S—, (C1-4-alkyl)3Si—, nitro, amino, (C1-4-alkyl)2N—, (H2N)—C(O)—, (C1-4-alkyl)-HN—C(O)—, (C1-4-alkyl)2N—C(O)—, C1-4-alkyl-O—C1-4-alkyl- and C1-6-alkyl- which is optionally fluorinated with 1 to 13 fluorine atoms; R7 is selected from the group R7a consisting of
H and C1-5-alkyl- which is optionally fluorinated with 1 to 13 fluorine atoms, or a salt thereof. |
