Spiropyrrolidine beta-secretase inhibitors for the treatment of alzheimer'S disease

摘要

The present invention is directed to spiropyrrolidine compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.;

主权项

1. A compound of formula (I)wherein:
R1 is selected from the group consisting of
(1) hydrogen(2) C1-6alkyl,(3) C3-9 cycloalkyl, and(4) phenyl,wherein said alkyl, cycloalkyl or phenyl R1 moiety is optionally substituted with one or more
(a) halo,(b) —OH,(c) —CN,(d) —C1-6 alkyl(e) —C3-6 cycloalkyl, or(f) —O—C1-6 alkyl; R2 is hydrogen; R3 is selected from the group consisting of:
(1) hydrogen,(2) C6-10aryl (for example, phenyl), and(3) heteroaryl,wherein said aryl or heteroaryl R3 moiety is optionally substituted with one or more
(a) halo,(b) —C1-6 alkyl, wherein said alkyl is optionally substituted with one or more halogen, and(c) —O—C1-6 alkyl; R11 is selected from the group consisting of
(1) hydrogen(2) C1-6alkyl,(3) C3-6 cycloalkyl, and(4) phenyl,
wherein said alkyl, cycloalkyl or phenyl R11 moiety is optionally substituted with one or more(a) halo,(b) —OH,(c) —CN,(d) —C1-6 alkyl(e) —C3-6 cycloalkyl, or(f) —O—C1-6 alkyl.