| 主权项 |
1. A method for treating wrinkles and/or fine lines on human skin comprising topically applying to an area of the skin in need thereof a composition comprising an effective amount of a compound according to formula I(a): wherein, L is a bond or a divalent radical selected from —(C═O)—, —O—(C═O)—, —N(R*)—(C═O)—, —(CH2)k—, —O—(CH2)k—, —N(R*)—(CH2)k—, —(CH2)k—(C═O)—, —(CH2)k—O—(C═O)—, —(CH2)k—N(R*)—(C═O)—, where K is an integer from 1-3; Q represents a five-membered heterocyclic ring selected from the following: wherein ε1, ε2, and ε3, are independently selected from N, NH, NR*, S, and O; with the proviso that where the point of attachment is ε1, ε2, or ε3, then that position represents N; and wherein carbon atoms which are not the point of attachment may be optionally substituted with a group R; and wherein the dashed circles indicate that each ring may comprise zero, one, or two double bonds; R1-R5 are independently selected, at each occurrence, from a group R; wherein R is selected from hydrogen, —F; —Cl; —Br; —I; —OH, —OR*; —NH2; —NHR*; —N(R*)2; —N(R*)3+; —N(R*)—OH; —N(→O)(R*)2; —O—N(R*)2; —N(R*)—O—R*; —N(R*)—N(R*)2; —C═N—R*; —N═C(R*)2; —C═N—N(R*)2; —C(═NR*)—N(R*)2; —SH; —SR*; —CN; —NC; —(C═O)—R*; —CHO; —CO2H; —CO2—; —CO2R*; —(C═O)—S—R*; —O—(C═O)—H; —O—(C═O)—R*; —S—(C═O)—R*; —(C═O)—NH2; —(C═O)—N(R*)2; —(C═O)—NHNH2; —O—(C═O)—NHNH2; —(C═S)—NH2; —(C═S)—N(R*)2; —N(R*)—CHO; —N(R*)—(C═O)—R*; —(C═NR)—O—R*; —O—(C═NR*)—R*, —SCN; —NCS; —NSO; —SSR*; —N(R*)—C(═O)—N(R*)2; —N(R*)—C(═S)—N(R*)2; —SO2—R*; —O—S(═O)2—R*; —S(═O)2—OR*; —N(R*)—SO2—R*; —SO2—N(R*)2; —O—SO3−; —O—S(═O)2—OR*; —O—S(═O)—OR*; —O—S(═O)—R*; —S(═O)—OR*; —S(═O)—R*; —NO; —NO2; —NO3; —O—NO; —O—NO2; —N3; —N2—R*; —N(C2H4); —Si(R*)3; —CF3; —O—CF3; —PR*2; —O—P(═O)(OR*)2; —P(═O)(OR*)2; perfluoroalkyl; an aliphatic C1-C12 hydrocarbon radical; a C1-C12 aromatic hydrocarbon radical; or a C1-C12 heteroaryl radical; where R* is independently at each occurrence hydrogen or a branched, cyclic, or straight chained C1-C20 hydrocarbon radical that is saturated, partially saturated, or aromatic, optionally substituted with 1-6 heteroatoms selected from nitrogen, oxygen, sulfur, or halogen; RN is hydrogen or a saturated, partially saturated, or aromatic C1-C20 hydrocarbon radical, optionally substituted with 1-6 heteroatoms selected from nitrogen, oxygen, sulfur, or halogen; and salts thereof, for a time sufficient to improve the appearance of wrinkles and/or fine lines on said human skin. |
