| 发明名称 | Small molecule inhibitors of RGS proteins | ||
| 摘要 | The invention relates to compositions having RGS (regulator of G-protein Signaling) inhibiting activity, and methods of use thereof. In some embodiments, RGS-inhibiting compositions find use in research on or treatment of disease states (e.g., diabetes, epilepsy, neuropathic pain, depression and other diseases). | ||
| 申请公布号 | US8865750(B2) | 申请公布日期 | 2014.10.21 |
| 申请号 | US201213458233 | 申请日期 | 2012.04.27 |
| 申请人 | The Regents of The University of Michigan;The University of Bath | 发明人 | Neubig Richard;Blazer Levi;Husbands Stephen;Larsen Scott;Traynor John |
| 分类号 | A01N43/82;A61K31/41;C07D417/00;C07D513/00;A61K31/433;C07D417/06;C07D285/08 | 主分类号 | A01N43/82 |
| 代理机构 | Casimir Jones, S.C. | 代理人 | Arenson Tanya A.;Casimir Jones, S.C. |
| 主权项 | 1. A composition comprising a compound having the structure:wherein R1 is selected from the group consisting ofC2-C4 alkyl-OR3, C1-C3 alkyl-heteroaryl-R3, C4-C10 cycloalkyl wherein one or more CH2 is replaced by O, and C2-C6 alkynyl, optionally substituted; R2 is a C2-C4 alkyl; R3 is selected from the group consisting of C1-C6 alkyl, C0-C4 alkyl-aryl, C0-C4 alkyl-heteroaryl, and C2-C4 alkyl-OR4; and R4 is C1-C4 alkyl. | ||
| 地址 | Ann Arbor MI US | ||